DAP helps calm dogs that are upset by thunderstorms, separation, new pets or people in the home. Convenient and portable for use in the home or for travel. Wipe the inside of the crate before putting the dog inside to help settle the animal. Wipe the inside of the car before transporting your dog to the vet. Helps calm puppies using the same pheromone as the mother dog when she is nursing her pups. Rub the wipe inside crates, on furniture, car interior or other areas. Apply until the wipe starts to dry. Effect lasts approx 1 1/2 to 2 hours.